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Invitrogen
MBP Monoclonal Antibody (7G7)
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FIGURE: 1 / 5
MBP Antibody (MA5-47370) in ICC/IF
Immunocytochemistry analysis of MBP in rat mixed neuron/glial cultures. Samples were stained with MBP monoclonal antibody (Product # MA5-47469) in red. Blue is a DNA stain. Note that the Myelin Basic Protein antibody stains an oligodendrocyte and some membrane shed from this cell. Other cells in the field include neurons, astrocytes, microglia and fibroblasts, all of which are completely negative with this antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-47370
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Horse,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
7G7
Immunogen
Purified myelin basic protein isolated from bovine brain, epitope is in peptide TPPPSQGKG, amino acids 125-133 of the human 21.5kDa sequence
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
14-21.5 kDa rodent, 17.2-21.5 kDa human
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17.3K myelin basic protein; 20 kDa microtubule-stabilizing protein; alternate; golli mbp; MBP; MBP S; MGC99675; microtubule-stabilizing protein; myelin A1 protein; myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; myelin membrane encephalitogenic protein; shiverer; unnamed protein product
Gene Aliases: golli-mbp; Hmbpr; jve; Mbps; mld; shi
UniProt ID: (Human) P02686, (Rat) P02688, (Mouse) P04370
Entrez Gene ID: (Pig) 414286, (Human) 4155, (Bovine) 618684, (Horse) 100063306, (Rat) 24547, (Mouse) 17196
immune response
chemical synaptic transmission
central nervous system development
axon ensheathment
myelin assembly
myelination
membrane organization
sensory perception of sound
response to toxic substance
response to progesterone
response to tumor necrosis factor
response to mercury ion
negative regulation of axonogenesis
response to fatty acid
MAPK cascade
positive regulation of interleukin-6 production
negative regulation of heterotypic cell-cell adhesion
maintenance of blood-brain barrier
positive regulation of chemokine (C-X-C motif) ligand 2 production
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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