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Invitrogen

Aldolase A/B/C Monoclonal Antibody (E9)

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Aldolase A/B/C Monoclonal Antibody (E9)

Product Details

MA5-47377

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000
-

Immunohistochemistry (IHC)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000-1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

E9

Immunogen

Recombinant human full-length aldolase C
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942359

Target Information

Aldolases are important glycolytic cytosolic enzymes which catalyse the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate. There are three aldolase isozymes coded by three distinct genes in mammals, namely aldolases A, B, and C. Aldolase A is heavily expressed in muscle enzyme and aldolase B is heavily expressed in liver and is regarded as a liver specific enzyme. In the adult, aldolase C is the brain-specific isozyme expressed in astrocytes and a few classes of neurons, notably Purkinje cells. Appropriate antibodies to aldolase C are therefore useful to identify astrocytes in cell culture and sectioned material, and the enzyme may be over expressed in some forms of cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ALDA; ALDB; ALDC; ALDOA; ALDOC; aldolase 2; aldolase 3; aldolase A; aldolase A (EC 4.1.2.13); aldolase A (EC 4.1.3.13); aldolase A, fructose-bisphosphate; aldolase B; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; brain-type aldolase; epididymis secretory sperm binding protein; epididymis secretory sperm binding protein Li 87p; fructoaldolase C; fructose 1,6-diphosphate aldolase A (EC 4.1.2.13); fructose-1,6-biphosphate triosephosphate lyase; fructose-1,6-bisphosphate triosephosphate-lyase; gluconeogenic enzyme; ALDOA_V1; gluconeogenic enzyme; ALDOA_V2; liver-type aldolase; lung cancer antigen NY-LU-1; muscle-type aldolase; scrapie responsive gene 2; scrapie-responsive protein 2; unnamed protein product; zebrin II

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Gene Aliases: ALDA; ALDB; ALDC; ALDCAA; Aldo-1; Aldo-2; Aldo1; ALDO2; Aldo3; F16dip7; GSD12; HEL-S-87p; LIV10; RATALDCAA; RNALDOG5; Scrg2

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UniProt ID: (Human) P04075, (Human) P05062, (Human) P09972, (Rat) P05065, (Mouse) P05064, (Mouse) Q91Y97, (Rat) P09117, (Mouse) P05063

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Entrez Gene ID: (Human) 226, (Human) 229, (Human) 230, (Rat) 24189, (Mouse) 11674, (Rat) 24190, (Mouse) 230163, (Rat) 24191, (Mouse) 11676

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Function(s)
RNA binding actin binding fructose-bisphosphate aldolase activity protein binding cytoskeletal protein binding tubulin binding identical protein binding cadherin binding fructose binding ATPase binding binding, bridging fructose-1-phosphate aldolase activity protease binding phosphatidylcholine binding macromolecular complex binding
Process(es)
response to hypoxia fructose metabolic process glycolytic process ATP biosynthetic process striated muscle contraction binding of sperm to zona pellucida regulation of cell shape methylglyoxal biosynthetic process fructose 1,6-bisphosphate metabolic process response to lipopolysaccharide response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus response to estrogen muscle cell cellular homeostasis protein homotetramerization canonical glycolysis gluconeogenesis epithelial cell differentiation organ regeneration hexose metabolic process positive regulation of cell migration cellular response to glucose starvation glycolytic process through fructose-6-phosphate liver development fructose catabolic process response to xenobiotic stimulus response to carbohydrate response to fructose response to zinc ion cellular response to insulin stimulus response to starvation response to amino acid response to peptide hormone response to copper ion response to glucocorticoid response to cAMP vacuolar proton-transporting V-type ATPase complex assembly response to interleukin-6 negative regulation of pentose-phosphate shunt glycolytic process through fructose-1-phosphate actin filament organization
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