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Invitrogen

PLCG1 Monoclonal Antibody (M156)

View all (46) PLCG1 antibodies

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Product Details

MA5-47678

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

M156

Immunogen

Clone (M156) was generated from a synthetic peptide corresponding to amino acids in the N-terminal region of human PLCgamma1. This sequence is highly conserved in rat and mouse PLCgamma1, and has low homology to PLCgamma2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.125 mg/mL

Amount

12.5 µg

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942659

Product Specific Information

The antibody detects a 150 kDa* protein in human A431, Hct116, and Jurkat cells, as well as in mouse brain.

Target Information

The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; cell differentiation and embryonic development; EC 3.1.4.11; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; OTTHUMP00000178982; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-gamma-1; phospholipase C; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-1; phospholipase C-148; phospholipase C-gamma; phospholipase C-II; Phospholipase C2; PLC gamma1; PLC-148; PLC-gamma-1; PLC-II; PLC2I; similar to PLC gamma 1; triphosphoinositide phosphodiesterase; unnamed protein product

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Gene Aliases: Cded; IDAA; NCKAP3; Plc-1; Plc-gamma1; PLC-II; PLC1; PLC148; Plcg-1; PLCgamma1; PPLCA

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UniProt ID: (Human) P19174, (Rat) P10686, (Mouse) Q62077

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Entrez Gene ID: (Human) 5335, (Rat) 25738, (Mouse) 18803

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Function(s)
phosphatidylinositol phospholipase C activity phospholipase C activity guanyl-nucleotide exchange factor activity neurotrophin TRKA receptor binding calcium ion binding protein binding phosphoric diester hydrolase activity protein kinase binding phosphatidylinositol phospholipase C activity lysophospholipase C activity insulin receptor binding receptor tyrosine kinase binding glutamate receptor binding phosphoprotein binding
Process(es)
in utero embryonic development lipid metabolic process calcium ion transport signal transduction epidermal growth factor receptor signaling pathway phospholipid catabolic process response to gravity positive regulation of epithelial cell migration cell migration calcium-mediated signaling positive regulation of cell migration phosphatidylinositol catabolic process inositol trisphosphate metabolic process inositol trisphosphate biosynthetic process intracellular signal transduction response to hydrogen peroxide positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of cell size phosphatidylinositol metabolic process phosphatidylinositol-mediated signaling modulation of synaptic transmission T cell receptor signaling pathway release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol cellular response to epidermal growth factor stimulus positive regulation of wound healing regulation of store-operated calcium channel activity response to curcumin positive regulation of vascular endothelial cell proliferation positive regulation of endothelial cell apoptotic process negative regulation of inflammatory response to antigenic stimulus Fc-epsilon receptor signaling pathway antigen receptor-mediated signaling pathway
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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