Search
Invitrogen
JAM-A (CD321) Monoclonal Antibody (M.Ab.F11)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-49041
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
M.Ab.F11
Immunogen
Human platelet membranes
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
100 µg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1.
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. CD321 is a 32-41 kD glycoprotein, possessing two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein assembles at the membrane as a homodimer, and can associate laterally with other membrane proteins including integrins. CD321 is expressed on a variety of cell types, including leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and plays a role in mediating cell-cell contact. CD321 can be found in close proximity to several components of epithelial tight junctions, including ZO-1 and occludin. CD321 is involved in the maintenance of epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: F11 R; F11R; immunoglobulin superfamily; JAM-1; platelet adhesion molecule PAM-1; junctional adhesion molecule 1; platelet adhesion molecule 1; platelet F11 receptor; platelet membrane glycoprotein; unnamed protein product
Gene Aliases: CD321; JAM; JAM1; JAMA; JCAM; KAT; PAM-1
UniProt ID: (Human) Q9Y624
Entrez Gene ID: (Human) 50848
regulation of cytokine production
system process
inflammatory response
cell adhesion
leukocyte cell-cell adhesion
regulation of cell shape
cell differentiation
actomyosin structure organization
regulation of actin cytoskeleton organization
positive regulation of Rho protein signal transduction
maintenance of blood-brain barrier
memory T cell extravasation
intestinal absorption
leukocyte migration
regulation of cytoskeleton organization
negative regulation of stress fiber assembly
cellular response to mechanical stimulus
protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of membrane permeability
cell-cell adhesion
positive regulation of platelet aggregation
protein localization to bicellular tight junction
positive regulation of establishment of endothelial barrier
regulation of bicellular tight junction assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support