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Invitrogen
CtBP2 Monoclonal Antibody (7F3E1)
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FIGURE: 1 / 9
CtBP2 Antibody (MA5-49228) in IHC (P)
Immunohistochemistry analysis of CtBP2 in paraffin-embedded section of human laryngeal squamous cell carcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with CtBP2 Monoclonal antibody (Product # MA5-49228) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjuga... View More
Product Details
MA5-49228
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
7F3E1
Immunogen
E.coli-derived human CTBP2 recombinant protein (Position: H321-Q445).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Human CTBP2 shares 99.2% and 98.4% amino acid (aa) sequence identity with mouse and rat CTBP2, respectively.
Positive Control - WB: human Hela whole cell, human SiHa whole cell, human COLO 320 whole cell, human SW620 whole cell ysates, rat stomach tissue, rat brain tissue, mouse stomach tissue, mouse brain tissue. IHC: human colorectal adenocarcinoma tissue, human liver cancer tissue, human placenta tissue, human thyroid cancer tissue, human laryngeal squamous cell carcinoma tissue, mouse colon tissue, rat colon tissue. Flow: U87 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21. 3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal-binding protein 2; CTBP2; gene trap ROSA b-geo 6; phosphoprotein; CtBP; transcriptional corepressor; ribeye; RP11-59C5.2; unnamed protein product
Gene Aliases: AA407280; CTBP2; D7Ertd45e; Gtrgeo6; Ribeye
UniProt ID: (Human) P56545, (Rat) Q9EQH5, (Mouse) P56546
Entrez Gene ID: (Human) 1488, (Rat) 81717, (Mouse) 13017
transcription cofactor binding
transcription corepressor binding
transcription coactivator activity
transcription corepressor activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
protein kinase binding
identical protein binding
macromolecular complex binding
NAD binding
DNA-binding transcription factor binding
chromatin binding
retinoic acid receptor binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
viral genome replication
cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of retinoic acid receptor signaling pathway
white fat cell differentiation
transcription, DNA-templated
positive regulation of chromatin binding
oxidation-reduction process
regulation of transcription, DNA-templated
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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