Search
Invitrogen
TRPM8 Recombinant Rabbit Monoclonal Antibody (2G7)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
TRPM8 Antibody (MA5-49869) in IHC (P)
Immunohistochemistry analysis with a TRPM8 monoclonal antibody (Product # MA5-49869) using a dilution of 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was inc... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-49869
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2G7
Immunogen
A synthesized peptide derived from human TRPM8
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: calcium channel; cation channel; MGC2849; short form of the TRPM8 cationic channel; sTRPM8-18; 18kDa non-channel protein; sM8alpha; sTRPM8-18; 18kDa non-channel protein; sTRPM8(2p-6b/+3pp); sTRPM8-26; 26kDa non-channel protein; sTRPM8(1-6b); sTRPM8-9; 9kDa non-channel protein; sM8beta; sTRPM8-9; 9kDa non-channel protein; sTRPM8(3p-6b); transient receptor potential p8; transient receptor potential subfamily M member 8; transmembrane ion channel; TRP-P8; TRPM8 cationic channel; TRPM8 channel; TRPM8 isoform; 118kDa channel protein; TRPM8(3p-22b); TRPM8 isoform; 119kDa channel protein; TRPM8(3p-26.2); TRPM8 isoform; 121kDa channel protein; TRPM8(1-22p); TRPM8 isoform; 121kDa channel protein; TRPM8(2p-26.1); TRPM8 isoform; 127kDa channel protein; TRPM8(1-22b); TRPM8 isoform; 26kDa channel protein; TRPM8(18a-26.2); TRPM8 isoform; 27kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 27kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 35kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 35kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 76kDa channel protein; TRPM8(9p-22p); TRPM8 isoform; 83kDa channel protein; TRPM8(5a-26.2); TRPM8 isoform; 83kDa channel protein; TRPM8(9p-26.2); TRPM8 isoform; putative 106kDa channel protein; TRPM8(3p-26.2/+intron3p; TRPM8 isoform; putative 122kDa channel protein; TRPM8(3p-26.2/+intron3p); TRPM8 isoform; putative 17kDa non-channel protein; TRPM8(15a-26.2/-16b; TRPM8 isoform; putative 23kDa channel protein; TRPM8(16a-26.2/+intron16; TRPM8 isoform; putative 29kDa channel protein; TRPM8(17p-22p); TRPM8 isoform; putative 33kDa channel protein; TRPM8(18a-26.2/-23; TRPM8 isoform; putative 35kDa channel protein; TRPM8(17pp-22b); TRPM8 isoform; putative 37kDa channel protein; TRPM8(17pp-26.2/-25); TRPM8 isoform; putative 50kDa channel protein; TRPM8(16a-26.2/+intron16); TRPM8 isoform; putative 51kDa protein; TRPM8(2p-26.2/+4a; TRPM8 isoform; putative 73kDa channel protein; TRPM8(3p-26.2/+16d); TRPM8 isoform; putative 83kDa channel protein; TRPM8(3p-26.1/-7); TRPM8 isoform; putative 95kDa channel protein; TRPM8(3p-22b/-4b; unnamed protein product
Gene Aliases: LTrpC-6; LTRPC6; trp-p8; TRPP8
UniProt ID: (Human) Q7Z2W7
Entrez Gene ID: (Human) 79054
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support