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Invitrogen
Huntingtin Recombinant Rabbit Monoclonal Antibody (6F2)
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Huntingtin Antibody (MA5-49884) in IHC (P)
Immunohistochemistry analysis with a Huntingtin monoclonal antibody (Product # MA5-49884) using a dilution of 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-49884
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6F2
Immunogen
A synthesized peptide derived from human Huntingtin
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.63 mg/mL
Amount
63 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: huntington disease protein; unnamed protein product
Gene Aliases: HD; IT15; LOMARS
UniProt ID: (Human) P42858
Entrez Gene ID: (Human) 3064
establishment of mitotic spindle orientation
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based process
Golgi organization
central nervous system development
regulation of signal transduction
endosomal transport
neurogenesis
protein destabilization
vocal learning
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of cilium assembly
vesicle transport along microtubule
synaptic vesicle transport
positive regulation of calcium-mediated signaling
positive regulation of mitophagy
positive regulation of lipophagy
regulation of CAMKK-AMPK signaling cascade
positive regulation of CAMKK-AMPK signaling cascade
positive regulation of aggrephagy
negative regulation of extrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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