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Invitrogen

LRP1 Monoclonal Antibody (D3)

View all (46) LRP1 (CD91) antibodies

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LRP1 Monoclonal Antibody (D3)

Product Details

MA5-51003

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

D3

Immunogen

Recombinant Human LRP1 protein, Val4441-Ala4544 (Accession #Q07954)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3090590

Target Information

CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-2-macroglobulin receptor; apolipoprotein E receptor; FLJ16451; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); MGC88725; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor

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Gene Aliases: A2MR; APOER; APR; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP-1; LRP1A; TGFBR5

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UniProt ID: (Human) Q07954, (Rat) G3V928

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Entrez Gene ID: (Human) 4035, (Rat) 299858

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Function(s)
beta-amyloid binding virus receptor activity RNA binding low-density lipoprotein receptor activity scavenger receptor activity calcium ion binding protein binding alpha-2 macroglobulin receptor activity apolipoprotein receptor activity clathrin heavy chain binding apolipoprotein binding signaling receptor activity cargo receptor activity heparan sulfate proteoglycan binding macromolecular complex binding lipoprotein particle receptor binding protease binding receptor binding coreceptor activity protein serine/threonine kinase binding
Process(es)
astrocyte activation involved in immune response outflow tract morphogenesis atrioventricular valve development cardiac septum development receptor-mediated endocytosis phagocytosis apoptotic process lysosomal transport enzyme linked receptor protein signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of cytosolic calcium ion concentration heart development cholesterol metabolic process cell proliferation gene expression negative regulation of gene expression negative regulation of cell-substrate adhesion positive regulation of cholesterol efflux positive regulation of neuron projection development negative regulation of neuron projection development regulation of smooth muscle cell migration negative regulation of smooth muscle cell migration cell migration cerebral cortex development negative regulation of Wnt signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway receptor internalization positive regulation of lipid transport positive regulation of cholesterol transport regulation of actin cytoskeleton organization positive regulation of insulin secretion involved in cellular response to glucose stimulus aorta morphogenesis negative regulation of apoptotic process apoptotic cell clearance negative regulation of neuron apoptotic process positive regulation of axon extension positive regulation of endocytosis viral entry into host cell positive regulation of axon extension involved in regeneration positive regulation of collateral sprouting of injured axon cell motility positive regulation of phagocytosis positive regulation of protein transport negative regulation of cytosolic calcium ion concentration negative regulation of focal adhesion assembly negative regulation of SMAD protein import into nucleus coronary vasculature development chemoattraction of axon positive regulation of ERK1 and ERK2 cascade negative regulation of thrombin receptor signaling pathway beta-amyloid clearance regulation of postsynaptic neurotransmitter receptor internalization amyloid-beta clearance by transcytosis amyloid-beta clearance by cellular catabolic process transport across blood-brain barrier positive regulation of Schwann cell migration positive regulation of beta-amyloid clearance regulation of extracellular matrix organization positive regulation of reverse cholesterol transport positive regulation of protein localization to plasma membrane positive regulation of cholesterol import positive regulation of transcytosis cellular response to beta-amyloid positive regulation of vascular associated smooth muscle cell migration regulation of pulmonary blood vessel remodeling positive regulation of lysosomal protein catabolic process positive regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of platelet-derived growth factor receptor-beta signaling pathway retinoid metabolic process lipid metabolic process regulation of extracellular matrix disassembly regulation of endocytosis lipoprotein transport transcytosis positive regulation of transport regulation of protein metabolic process
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