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Invitrogen
IL-21 Recombinant Rabbit Monoclonal Antibody (145)
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Product Details
MA5-52226
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
145
Immunogen
Recombinant Human IL-21 Protein (Gln30-Ser162)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CX2; four helix bundle cytokine; il 21; ILN; Interleukin; Interleukin21
Gene Aliases: CVID11; IL-21; Za11
UniProt ID: (Human) Q9HBE4
Entrez Gene ID: (Human) 59067
positive regulation of cytokine production
germinal center B cell differentiation
positive regulation of immunoglobulin production
immune response
signal transduction
JAK-STAT cascade
tyrosine phosphorylation of STAT protein
positive regulation of cell proliferation
response to virus
immunoglobulin mediated immune response
natural killer cell activation
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of tissue remodeling
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of natural killer cell mediated cytotoxicity
cell development
cell maturation
positive regulation of inflammatory response
positive regulation of lymphocyte activation
defense response to virus
T follicular helper cell differentiation
cellular response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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