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Invitrogen
14-3-3 gamma Recombinant Rabbit Monoclonal Antibody (23GB1970)
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FIGURE: 1 / 4
14-3-3 gamma Antibody (MA5-53186) in ICC/IF
Immunocytochemistry analysis of 14-3-3 gamma in HepG2 cells. Nuclei were stained blue with DAPI; 14-3-3 gamma recombinant monoclonal antibody (Product # MA5-53186) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-53186
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB1970
Immunogen
A synthesized peptide derived from human 14-3-3 gamma (135-186AA).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
14-3-3 gamma encodes a product that belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma-subtype; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; KCIP-1; protein kinase C inhibitor protein 1; protein phosphatase 1, regulatory subunit 170; putative protein kinase C regulatory protein; signal transduction phosphoprotein; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; unnamed protein product; YWHAG
Gene Aliases: 14-3-3G; 14-3-3GAMMA; D7Bwg1348e; DEE56; EIEE56; PPP1R170
UniProt ID: (Human) P61981, (Mouse) P61982, (Rat) P61983
Entrez Gene ID: (Human) 7532, (Mouse) 22628, (Rat) 56010
RNA binding
protein kinase C binding
insulin-like growth factor receptor binding
protein binding
protein kinase C inhibitor activity
protein domain specific binding
receptor tyrosine kinase binding
identical protein binding
phosphorylation-dependent protein binding
protein sequestering activity
actin binding
enzyme regulator activity
cytoplasmic translation
negative regulation of T cell mediated immune response to tumor cell
positive regulation of T cell mediated immune response to tumor cell
protein targeting
signal transduction
protein localization
positive regulation of cell-cell adhesion
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
cellular response to nutrient levels
cellular response to insulin stimulus
regulation of protein localization
cellular response to amino acid starvation
TORC1 signaling
cellular response to glucose starvation
proteasome-mediated ubiquitin-dependent protein catabolic process
establishment of protein localization
regulation of neuron differentiation
negative regulation of translational initiation
positive regulation of translational initiation
regulation of synaptic plasticity
protein stabilization
negative regulation of T cell activation
positive regulation of T cell activation
protein localization to lysosome
protein K6-linked ubiquitination
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
negative regulation of protein kinase activity
regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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