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Invitrogen

HSP60 Recombinant Rabbit Monoclonal Antibody (23GB2680)

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HSP60 Recombinant Rabbit Monoclonal Antibody (23GB2680)

Product Details

MA5-53492

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:200-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB2680

Immunogen

A synthesized peptide derived from human Hsc60 (420-460AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Amount

80 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3247963

Target Information

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 60 kDa chaperonin; 60 kDa heat shock protein; a stress-inducible molecular chaperone which participates in protein folding; chaperonin; chaperonin (HSP60); chaperonin 60; CPN60; epididymis secretory sperm binding protein; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock 60kDa protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_1; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_2; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_4; Heat shock protein; heat shock protein 1 (chaperonin); heat shock protein 60; heat shock protein 60 (liver); heat shock protein 65; heat shock protein family D member 1; heat shock protein, 60 kDa; HSP; HSP-60; HSP-65; Hsp60s1; mitochondrial matrix protein P1; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; unnamed protein product

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Gene Aliases: 60kDa; CPN60; GROEL; HLD4; HSP-60; HSP-65; HSP60; HSP65; Hspd1-30p; HuCHA60; SPG13

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UniProt ID: (Human) P10809, (Mouse) P63038, (Rat) P63039

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Entrez Gene ID: (Human) 3329, (Mouse) 15510, (Rat) 63868

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Function(s)
lipopolysaccharide binding p53 binding DNA replication origin binding single-stranded DNA binding RNA binding double-stranded RNA binding protein binding ATP binding high-density lipoprotein particle binding ATPase activity enzyme binding ubiquitin protein ligase binding apolipoprotein binding apolipoprotein A-I binding chaperone binding cysteine-type endopeptidase activator activity ATP-dependent protein folding chaperone macromolecular complex binding modification-dependent protein binding
Process(es)
response to hypoxia positive regulation of cytokine production MyD88-dependent toll-like receptor signaling pathway positive regulation of T cell mediated immune response to tumor cell response to ischemia protein folding response to unfolded protein apoptotic mitochondrial changes response to cold response to xenobiotic stimulus response to activity response to lipopolysaccharide positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production response to ATP mitochondrial unfolded protein response cellular response to heat protein refolding B cell proliferation T cell activation B cell activation response to cocaine response to hydrogen peroxide positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of neuron apoptotic process response to estrogen adhesion of symbiont to host protein import into mitochondrial intermembrane space isotype switching to IgG isotypes protein stabilization positive regulation of T cell activation response to glucocorticoid interaction with symbiont negative regulation of apoptotic process in bone marrow cellular response to interleukin-7 negative regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis negative regulation of reactive oxygen species biosynthetic process response to resveratrol 'de novo' protein folding chaperone-mediated protein complex assembly protein maturation
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