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Invitrogen

hnRNP K Recombinant Rabbit Monoclonal Antibody (23GB4825)

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hnRNP K Recombinant Rabbit Monoclonal Antibody (23GB4825)

Product Details

MA5-53812

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB4825

Immunogen

A synthesized peptide derived from human hnRNP K (1-53AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3248283

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progression. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dC stretch-binding protein; dC-stretch binding protein; FLJ41122; hnRNP K; HNRPK; RNA binding protein; RP11-575L7.1; transformation upregulated nuclear protein; unnamed protein product

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Gene Aliases: AUKS; CSBP; HNRPK; KBBP; NOVA; TUNP

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UniProt ID: (Human) P61978, (Mouse) P61979, (Rat) P61980

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Entrez Gene ID: (Human) 3190, (Mouse) 15387, (Rat) 117282

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Function(s)
nucleic acid binding RNA binding mRNA binding protein binding protein domain specific binding identical protein binding cadherin binding core promoter proximal region sequence-specific DNA binding double-stranded DNA binding single-stranded DNA binding mRNA 3'-UTR binding lamin binding pre-mRNA 3'-splice site binding heat shock protein binding actinin binding ribonucleoprotein complex binding ATPase binding lncRNA binding mRNA CDS binding C-rich single-stranded DNA binding
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter negative regulation of gene expression chromatin silencing by small RNA regulation of apoptotic process negative regulation of apoptotic process regulation of RNA splicing negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of mRNA splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome random inactivation of X chromosome regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of low-density lipoprotein particle clearance mRNA splicing, via spliceosome RNA processing signal transduction negative regulation of transcription from RNA polymerase II promoter ovarian follicle development kidney development liver development acute-phase response peripheral nervous system development male gonad development positive regulation of neuron projection development response to activity cerebellum development hippocampus development cerebral cortex development lung development positive regulation of myelination cellular response to insulin stimulus positive regulation of RNA splicing camera-type eye development thymus development modulation of synaptic transmission positive regulation of synaptic transmission positive regulation of dendritic spine development cellular response to amino acid stimulus cellular response to lead ion cellular response to glucose stimulus cellular response to rapamycin positive regulation of synapse maturation regulation of postsynapse organization positive regulation of long-term synaptic potentiation response to salt positive regulation of dendrite extension cellular response to forskolin positive regulation of protein localization to cell surface negative regulation of branching morphogenesis of a nerve
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