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Invitrogen
IL23R VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1299)
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Product Details
MA5-54613
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1299
Immunogen
Recombinant Human IL23R.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.9 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hemopoietic cytokine receptor; IBD17; IL 23R; IL-23 receptor; IL-23R endodomain protein; IL-23R3-F3; IL-23R soluble receptor; IL-23R2-F1; IL-23R soluble receptor; IL-23R3-F1; IL-23R soluble receptor; IL-23R4; IL-23R truncated endodomain protein; IL-23R2-F2; IL23RL1-THE1A; type I cytokine receptor; IL-23R1
Gene Aliases: PSORS7
UniProt ID: (Human) Q5VWK5
Entrez Gene ID: (Human) 149233
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
immune response
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
response to lipopolysaccharide
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
response to interferon-gamma
interleukin-23-mediated signaling pathway
prolactin signaling pathway
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
positive regulation of osteoclast differentiation
positive regulation of JAK-STAT cascade
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
receptor signaling pathway via STAT
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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