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Invitrogen
TNFR1 (Atrosimab Biosimilar) Recombinant Human Monoclonal Antibody
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FIGURE: 1 / 1
TNFR1 (Atrosimab Biosimilar) Antibody (MA5-54839) in SDS-PAGE
SDS-PAGE analysis of TNFR1 (Atrosimab Biosimilar). Samples were run under reducing (R) and non-reducing (NR) conditions using TNFR1 (Atrosimab Biosimilar) (Product # MA5-54839) monoclonal antibody. The purity of the protein is greater than 95%.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-54839
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant Human CD120a/TNFRSF1A/TNFR1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.48 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD120a antigen; MGC19588; n-smase activation assoc. factor; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF alpha gene; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; TNFR1 beta; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor; unnamed protein product
Gene Aliases: CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60
UniProt ID: (Human) P19438
Entrez Gene ID: (Human) 7132
aortic valve development
pulmonary valve development
negative regulation of extracellular matrix constituent secretion
prostaglandin metabolic process
apoptotic process
inflammatory response
signal transduction
activation of NF-kappaB-inducing kinase activity
JAK-STAT cascade
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to DNA damage
gene expression
regulation of gene expression
negative regulation of cardiac muscle hypertrophy
cytokine-mediated signaling pathway
tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
astrocyte activation
negative regulation of inflammatory response
positive regulation of inflammatory response
regulation of developmental process
regulation of multicellular organismal process
establishment of blood-brain barrier
cellular response to lipopolysaccharide
cellular response to mechanical stimulus
protein localization to plasma membrane
positive regulation of execution phase of apoptosis
positive regulation of apoptotic process involved in morphogenesis
regulation of establishment of endothelial barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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