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Invitrogen
FGF2/VEGF (Eflimrufusp Alfa Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-54882
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant Human FGF2/bFGF and VEGFA.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
FGF2 (Fibroblast Growth Factor 2, basic FGF) is a member of the FGF family that regulates cell proliferation, differentiation, and angiogenesis through high-affinity cell surface FGF receptors. The human FGF2 gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth. FGF2 exists as five isoforms generated by alternative translation from AUG and non-AUG (CUG) start codons. The 18 kDa isoform is mainly cytosolic and mediates paracrine and autocrine signaling through cell surface receptors. The higher molecular weight isoforms (22-34 kDa) localize to the nucleus and function through intracrine mechanisms independent of membrane receptors. Dysregulation of FGF2 has been associated with diseases such as Kaposi sarcoma and corneal neovascularization.
VEGF (Vascular Endothelial Growth Factor) is a 45 kDa homodimeric, disulfide-linked glycoprotein that is a central regulator of angiogenesis and tumor progression. It promotes endothelial cell survival, proliferation, migration, and vascular permeability. The VEGF family includes VEGF-A, -B, -C, -D, -E, and PlGF. VEGF signals primarily through the tyrosine kinase receptors VEGFR-1 (FLT1) and VEGFR-2 (KDR/FLK1), expressed mainly on endothelial cells. These pathways are essential for embryonic vascular development and tumor angiogenesis. Alternative splicing produces multiple VEGF isoforms with distinct properties. A soluble form of VEGFR-1 (sFLT1) can bind VEGF and inhibit angiogenesis. Elevated VEGF levels are associated with POEMS syndrome (Crow-Fukase syndrome).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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