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Invitrogen
HSD3B1/HSD3B2 Recombinant Rabbit Monoclonal Antibody (HL2307)
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FIGURE: 1 / 2
HSD3B1/HSD3B2 Antibody (MA5-56747) in WB
Western Blot analysis of HSD3B1/HSD3B2 using HSD3B1/HSD3B2 Recombinant Monoclonal Antibody (Product # MA5-56747). Mouse adrenal gland and mouse muscle tissue extracts (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with HSD3B1/HSD3B2 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-56747
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL2307
Immunogen
Recombinant fragment of human HSD3B2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
HSD3B1 and HSD3B2 (Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- and Steroid Delta-Isomerase 1 and 2) are genes that encode enzymes crucial for the biosynthesis of all classes of hormonal steroids, including glucocorticoids, mineralocorticoids, androgens, and estrogens. These enzymes catalyze the conversion of delta-5-3-beta-hydroxysteroids into delta-4-3-ketosteroids, a key step in the steroidogenesis pathway. HSD3B1 is predominantly expressed in the placenta and peripheral tissues, while HSD3B2 is mainly found in the adrenal glands and gonads. Mutations or dysregulation in these genes can lead to various disorders, such as congenital adrenal hyperplasia, which affects steroid hormone production and can result in a range of clinical symptoms from salt-wasting crises to ambiguous genitalia. Given their fundamental role in steroid metabolism, HSD3B1 and HSD3B2 are important targets for understanding and treating endocrine disorders and diseases related to steroid hormone imbalance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3 beta-HSD type II; 3 beta-hydroxy-5-ene steroid dehydrogenase; 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD adrenal and gonadal type; 3-beta-HSD I; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3-beta-hydroxysteroid dehydrogenase/5-4-isomerase; delta 5-delta 4-isomerase type II; delta-5-3-ketosteroid isomerase; dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; progesterone reductase; short chain dehydrogenase/reductase family 11E, member 1; short chain dehydrogenase/reductase family 11E, member 2; steroid Delta-isomerase; trophoblast antigen FDO161G; unnamed protein product
Gene Aliases: 3-beta-HSD I; 3-beta-HSD II; 3BETAHSD; D3Ertd383e; HSD3B; HSDB; HSDB3; HSDB3A; SDR11E1; SDR11E2
UniProt ID: (Human) P14060, (Human) P26439, (Mouse) P24815, (Mouse) P26149
Entrez Gene ID: (Human) 3283, (Human) 3284, (Mouse) 15492, (Mouse) 15493
3-keto sterol reductase activity
3-beta-hydroxy-delta5-steroid dehydrogenase activity
steroid delta-isomerase activity
protein binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
steroid binding
NAD binding
steroid biosynthetic process
progesterone biosynthetic process
androgen biosynthetic process
estrogen biosynthetic process
C21-steroid hormone metabolic process
glucocorticoid biosynthetic process
cortisol biosynthetic process
C21-steroid hormone biosynthetic process
negative regulation of iron ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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