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Invitrogen

GluR6 Recombinant Rabbit Monoclonal Antibody (24GB3695)

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GluR6 Recombinant Rabbit Monoclonal Antibody (24GB3695)

Product Details

MA5-57033

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

24GB3695

Immunogen

A synthesized peptide derived from human GRIK2 (aa 100-150)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.271 mg/mL

Amount

27.1 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3680059

Target Information

Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bA487F5.1; excitatory amino acid receptor 4; GLR 6; GluK2(alt_5'UTR); GLUR 6; gluR beta-2; gluR-6; glutamate receptor; glutamate receptor 6; glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; glutamate receptor, ionotropic, kainate 2; GRIK 2; GRIK2 protein; kainate 2; proteasome (prosome, macropain) subunit, alpha type 6 pseudogene; putative NMDtranscript(cassette_171nt); unnamed protein product

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Gene Aliases: C130030K03Rik; EAA4; GLR6; GluK2; GLUK6; Glur-6; GLUR6; Glurbeta2; MRT6; NEDLAS

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UniProt ID: (Human) Q13002, (Mouse) P39087, (Rat) P42260

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Entrez Gene ID: (Human) 2898, (Mouse) 14806, (Rat) 54257

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Function(s)
SNARE binding ionotropic glutamate receptor activity ion channel activity extracellular-glutamate-gated ion channel activity protein binding glutamate receptor activity ligand-gated ion channel activity kainate selective glutamate receptor activity glutamate-gated calcium ion channel activity PDZ domain binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding signaling receptor activity identical protein binding scaffold protein binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Process(es)
ion transport glutamate receptor signaling pathway chemical synaptic transmission calcium-mediated signaling ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic receptor clustering positive regulation of neuron apoptotic process regulation of JNK cascade regulation of short-term neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission neuron apoptotic process negative regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential modulation of excitatory postsynaptic potential regulation of presynaptic membrane potential detection of cold stimulus involved in thermoception behavioral fear response cellular calcium ion homeostasis intracellular protein transport neuronal action potential regulation of membrane potential negative regulation of neuron apoptotic process regulation of long-term neuronal synaptic plasticity inhibitory postsynaptic potential
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