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Invitrogen
MYF5 Recombinant Rabbit Monoclonal Antibody (24GB615)
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FIGURE: 1 / 3
MYF5 Antibody (MA5-57092) in ICC/IF
Immunocytochemistry analysis of MYF5 in HAP-1 cells. Sample was incubated with MYF5 monoclonal (Product # MA5-57091) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57092
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB615
Immunogen
A synthesized peptide derived from human MYF5 (aa 201-255)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.417 mg/mL
Amount
8.34 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Myogenic factor 5 (MYF5) is a gene located on chromosome 12q21.31, encoding a basic helix-loop-helix (bHLH) transcription factor essential for skeletal muscle development and differentiation. MYF5 is one of the key members of the myogenic regulatory factor (MRF) family, which also includes MyoD, myogenin, and MRF4. It plays a crucial role in myogenesis by regulating the expression of genes necessary for muscle precursor cell proliferation and differentiation into mature muscle fibers. During embryonic development, MYF5 is involved in the formation of muscle tissue and maintenance of muscle progenitor cells. Mutations or dysregulation in MYF5 can lead to developmental abnormalities in muscle formation and are implicated in muscle-related disorders. Research into MYF5 continues to explore its regulatory mechanisms in muscle biology and potential therapeutic applications in muscular dystrophies and muscle repair processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: class C basic helix-loop-helix protein 2; myf-5; unnamed protein product
Gene Aliases: bHLHc2; EORVA
UniProt ID: (Human) P13349
Entrez Gene ID: (Human) 4617
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
muscle organ development
skeletal muscle tissue development
tissue development
skeletal muscle cell differentiation
muscle cell fate commitment
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
animal organ development
positive regulation of skeletal muscle fiber development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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