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Pleiotrophin Recombinant Rabbit Monoclonal Antibody (24GB1110)
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FIGURE: 1 / 2
Pleiotrophin Antibody (MA5-57175) in ICC/IF
Immunocytochemical staining of Pleiotrophin in C2C12 cells using Pleiotrophin Recombinant Monoclonal Antibody (Product # MA5-57175) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; Pleiotrophin was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57175
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB1110
Immunogen
A synthesized peptide derived from human Pleiotrophin (aa 110-168)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HB-GAM; HBBM; HBGF-8; heparin affin regulatory protein; heparin affine regulatory peptide; heparin binding factor; heparin-binding brain mitogen; heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurotrophic factor; heparin-binding neutrophic factor; OSF-1; osteoblast-specific factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); PTN; unnamed protein product
Gene Aliases: HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBGF8; HBNF; HBNF-1; NEGF1; OSF; OSF-1; Osf1
UniProt ID: (Human) P21246, (Mouse) P63089, (Rat) P63090
Entrez Gene ID: (Human) 5764, (Mouse) 19242, (Rat) 24924
protein phosphatase inhibitor activity
integrin binding
protein binding
growth factor activity
heparin binding
protein kinase binding
carbohydrate binding
chondroitin sulfate binding
molecular function activator activity
glycosaminoglycan binding
chondroitin sulfate proteoglycan binding
vascular endothelial growth factor binding
proteoglycan binding
syndecan binding
heparan sulfate binding
ossification
leukocyte chemotaxis involved in inflammatory response
positive regulation of leukocyte chemotaxis
integrin-mediated signaling pathway
negative regulation of neuroblast proliferation
learning
memory
positive regulation of cell proliferation
regulation of cell shape
regulation of endothelial cell migration
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
response to auditory stimulus
dendrite development
negative regulation of angiogenesis
bone mineralization
negative regulation of cell migration
positive regulation of bone mineralization
dendrite regeneration
regulation of myelination
tissue regeneration
positive regulation of apoptotic process
receptor clustering
ossification involved in bone remodeling
estrous cycle
positive regulation of cell differentiation
positive regulation of ossification
negative regulation of membrane potential
decidualization
regulation of synaptic plasticity
oogenesis
positive regulation of axon regeneration
positive regulation of oligodendrocyte differentiation
negative regulation of epithelial cell proliferation
negative regulation of neurogenesis
modulation of synaptic transmission
positive regulation of developmental process
retinal rod cell differentiation
negative regulation of glial cell proliferation
negative regulation of mesenchymal cell proliferation
dendrite arborization
positive regulation of dendrite development
negative regulation of long-term synaptic potentiation
regulation of hemopoiesis
positive regulation of skeletal muscle acetylcholine-gated channel clustering
negative regulation of neuromuscular junction development
regulation of stem cell population maintenance
regulation of neural precursor cell proliferation
positive regulation of hepatocyte proliferation
positive regulation of stem cell differentiation
liver development
heart development
response to xenobiotic stimulus
response to activity
spinal cord development
cerebellum development
thalamus development
lung development
hindbrain development
response to estradiol
response to progesterone
cellular response to UV
cellular response to platelet-derived growth factor stimulus
endothelial cell differentiation
retina development in camera-type eye
long-term synaptic potentiation
cellular response to vitamin D
cellular response to hypoxia
response to kainic acid
rod bipolar cell differentiation
response to ciliary neurotrophic factor
cellular response to D-galactosamine
response to nerve growth factor
transmembrane receptor protein tyrosine phosphatase signaling pathway
nervous system development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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