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Invitrogen
VAV1/2/3 Recombinant Rabbit Monoclonal Antibody (24GB2645)
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FIGURE: 1 / 2
VAV1/2/3 Antibody (MA5-57313) in ICC/IF
Immunocytochemical staining of VAV1/2/3 in HepG2 cells using VAV1/2/3 Recombinant Monoclonal Antibody (Product # MA5-57313) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; Vav1/2/3 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57313
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB2645
Immunogen
A synthesized peptide derived from human Vav1/2/3 (aa 750-800)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
The VAV gene family consists of three members: VAV1, VAV2, and VAV3, which are guanine nucleotide exchange factors (GEFs) primarily involved in signal transduction. VAV1, located on chromosome 19p13.2, is predominant in hematopoietic cells and plays a crucial role in T and B lymphocyte signaling, impacting immune responses and cell cycle control. This gene has been implicated in autoimmune diseases as well as several cancers. VAV2, found on chromosome 9q34.1, is ubiquitously expressed and is involved in various cellular processes, such as DNA repair mechanisms and vascular smooth muscle function, with significant implications in cancer where overexpression correlates with tumor progression. VAV3, located on chromosome 1p13.3, shares similar GEF roles and is actively involved in oncogenic processes by mediating Rho GTPase signaling, affecting cell proliferation, migration, and invasion, and is considered a target for cancer therapy. The structural conservation and functional diversity of these proteins underscore their importance in both normal cellular function and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: guanosine nucleotide exchange factor; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav 2 oncogene; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV oncogene homolog; VAV-3
Gene Aliases: VAV; VAV-2
UniProt ID: (Human) P15498, (Human) P52735, (Human) Q9UKW4
Entrez Gene ID: (Human) 7409, (Human) 7410, (Human) 10451
immune response-regulating cell surface receptor signaling pathway
small GTPase mediated signal transduction
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell costimulation
intracellular signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
signal transduction
cellular response to DNA damage stimulus
positive regulation of B cell proliferation
B cell receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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