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Invitrogen
MFN1 Recombinant Rabbit Monoclonal Antibody (24GB4970)
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FIGURE: 1 / 4
MFN1 Antibody (MA5-57478) in ICC/IF
Immunocytochemistry analysis of MFN1 in C2C12 cells. Sample was incubated with MFN1 monoclonal (Product # MA5-57478) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB4970
Immunogen
A synthesized peptide derived from Rat Mitofusin 1 (aa 116-135)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.7 mg/mL
Amount
70 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762F247; EC 3.6.5; FLJ20693; fzo homolog; MFN1; putative mitochondrial transmembrane GTPase; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; mitochondrial transmembrane GTPase FZO1B; putative transmembrane GTPase; similar to Drosophila fuzzy onions encoded by GenBank Accession Number U95821; transmembrane GTPase; transmembrane GTPase MFN1; unnamed protein product
Gene Aliases: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; Fzo1b; hfzo1; hfzo2; HR2; mKIAA4032
UniProt ID: (Human) Q8IWA4, (Mouse) Q811U4, (Rat) Q8R4Z9
Entrez Gene ID: (Human) 55669, (Mouse) 67414, (Rat) 192647
mitochondrion organization
mitochondrial fusion
positive regulation of mitochondrial fusion
positive regulation of mitochondrial membrane potential
GTP metabolic process
intracellular distribution of mitochondria
mitochondrion localization
positive regulation of dendritic spine morphogenesis
negative regulation of mitochondrial fission
gonad development
male gonad development
response to manganese ion
response to muscle activity
response to nutrient levels
response to ethanol
response to corticosterone
response to calcium ion
response to electrical stimulus
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to dexamethasone stimulus
response to fluoride
response to flavonoid
response to hypobaric hypoxia
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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