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Invitrogen
PTBP1 Recombinant Rabbit Monoclonal Antibody (24GB1095)
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FIGURE: 1 / 5
PTBP1 Antibody (MA5-57652) in ICC/IF
Immunocytochemistry analysis of PTBP1 in HAP1 cells. Sample was incubated with PTBP1 monoclonal (Product # MA5-57652) antibody at a dilution of 1:1,000, followed by DAPI and Alexa Fluor 647. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB1095
Immunogen
A synthesized peptide derived from human PTBP1 (aa 20-68)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein; unnamed protein product
Gene Aliases: HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB1; PTB2; PTB3; PTB4; Pybp; Pybp1; Pybp2; STADS
UniProt ID: (Human) P26599, (Rat) Q00438, (Mouse) P17225
Entrez Gene ID: (Human) 5725, (Rat) 29497, (Mouse) 19205
regulation of alternative mRNA splicing, via spliceosome
mRNA processing
RNA splicing
negative regulation of gene expression
negative regulation of RNA splicing
regulation of RNA splicing
regulation of cell differentiation
negative regulation of neuron differentiation
negative regulation of mRNA splicing, via spliceosome
negative regulation of muscle cell differentiation
positive regulation of calcineurin-NFAT signaling cascade
IRES-dependent viral translational initiation
negative regulation of mRNA metabolic process
nuclear-transcribed mRNA catabolic process
cardiac ventricle development
positive regulation of neuron projection development
neurogenesis
positive regulation of insulin secretion
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
3'-UTR-mediated mRNA stabilization
positive regulation of secretory granule organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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