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Invitrogen
RARB Recombinant Rabbit Monoclonal Antibody (24GB1045)
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FIGURE: 1 / 4
RARB Antibody (MA5-57688) in ICC/IF
Immunocytochemical staining of RARB in HeLa cells using RARB Recombinant Monoclonal Antibody (Product # MA5-57688) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; Retinoic acid receptor beta was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57688
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
24GB1045
Immunogen
A synthesized peptide derived from human Retinoic Acid Receptor beta (aa 400-455)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.2 mg/mL
Amount
120 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; nuclear receptor subfamily 1 group B member 2; nuclear receptor; RAR beta; open reading frame 1; putative; RAR beta; RAR beta 1'; RAR-b; RAR-beta; RAR-Beta2; RAR-Beta4; RAR-epsilon; RARB; RARbeta isoform 5; retinoic acid; retinoic acid receptor; retinoic acid receptor, beta polypeptide; unnamed protein product
Gene Aliases: HAP; MCOPS12; NR1B2; RARbeta; RARbeta1; RRB2
UniProt ID: (Human) P10826
Entrez Gene ID: (Human) 5915
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
signal transduction
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
embryonic digestive tract development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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