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VE-cadherin Recombinant Rabbit Monoclonal Antibody (9W5E3)

View all (72) VE-cadherin (CD144) antibodies

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VE-cadherin Recombinant Rabbit Monoclonal Antibody (9W5E3)

Product Details

MA5-57859

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:8,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:800
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9W5E3

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 48-593 of human VE Cadherin (NP_001786.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Amount

2.6 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3680883

Product Specific Information

Immunogen sequence: DWIWNQMHID EEKNTSLPHH VGKIKSSVSR KNAKYLLKGE YVGKVFRVDA ETGDVFAIER LDRENISEYH LTAVIVDKDT GENLETPSSF TIKVHDVNDN WPVFTHRLFN ASVPESSAVG TSVISVTAVD ADDPTVGDHA SVMYQILKGK EYFAIDNSGR IITITKSLDR EKQARYEIVV EARDAQGLRG DSGTATVLVT LQDINDNFPF FTQTKYTFVV PEDTRVGTSV GSLFVEDPDE PQNRMTKYSI LRGDYQDAFT IETNPAHNEG IIKPMKPLDY EYIQQYSFIV EATDPTIDLR YMSPPAGNRA QVIINITDVD EPPIFQQPFY HFQLKENQKK PLIGTVLAMD PDAARHSIGY SIRRTSDKGQ FFRVTKKGDI YNEKELDREV YPWYNLTVEA KELDSTGTPT GKESIVQVHI EVLDENDNAP EFAKPYQPKV CENAVHGQLV LQISAIDKDI TPRNVKFKFI LNTENNFTLT DNHDNTANIT VKYGQFDREH TKVHFLPVVI SDNGMPSRTG TSTLTVAVCK CNEQGEFTFC EDMAAQ

Target Information

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); cd144 antigen; endothelial-specific cadherin; unnamed protein product; vascular endothelial cadherin; VE-cadherin

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Gene Aliases: 7B4; CD144

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UniProt ID: (Human) P33151

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Entrez Gene ID: (Human) 1003

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Function(s)
receptor binding calcium ion binding protein binding beta-catenin binding protein phosphatase binding receptor signaling complex scaffold activity vascular endothelial growth factor receptor 2 binding ion channel binding cadherin binding fibrinogen binding BMP receptor binding protein binding involved in cell-cell adhesion protein tyrosine kinase binding
Process(es)
cell morphogenesis endothelial cell morphogenesis cell migration involved in sprouting angiogenesis cellular calcium ion homeostasis cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of microtubule polymerization positive regulation of protein complex assembly adherens junction organization maintenance of blood-brain barrier regulation of vascular permeability blood vessel endothelial cell migration cell-cell adhesion mediated by cadherin positive regulation of angiogenesis negative regulation of inflammatory response bicellular tight junction assembly cell-cell adhesion protein localization to bicellular tight junction positive regulation of intracellular signal transduction positive regulation of establishment of endothelial barrier regulation of establishment of cell polarity negative regulation of endothelial cell apoptotic process
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