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Invitrogen
IFN beta Recombinant Rabbit Monoclonal Antibody (6K0L7)
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FIGURE: 1 / 1
IFN beta Antibody (MA5-57879) in WB
Western blot analysis of IFN beta in RAW 264.7 cell lysates (30 µg/lane). Raw264.7 cells were treated by DMXAA (50 µg/mL) for 7 hours after serum-starvation overnight. Samples were incubated with IFN beta Recombinant Monoclonal Antibody (Product # MA5-57880) using a dilution of 1:1, 000. Followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody at 1:10,000 dilution. Blocking buffer: 3% nonfat dry milk in TBST; Exposure: 20 seconds.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6K0L7
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of mouse IFN-beta (NP_034640.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.9 mg/mL
Amount
18 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: MNNRWILHAA FLLCFSTTAL SINYKQLQLQ ERTNIRKCQE LLEQLNGKIN LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IFN b; IFN β; IFNbeta; IFNβ; Interferon; interferon 1da1; Interferon b; RP11-113D19.1
Gene Aliases: If1da1; Ifb; IFN-beta; IFNB
UniProt ID: (Mouse) P01575
Entrez Gene ID: (Mouse) 15977
adaptive immune response
macrophage activation involved in immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
negative regulation of immunoglobulin production
negative regulation of immune system process
regulation of transcription from RNA polymerase II promoter
defense response
immune response
humoral immune response
signal transduction
JAK-STAT cascade
negative regulation of cell proliferation
positive regulation of autophagy
cytokine-mediated signaling pathway
negative regulation of interferon-gamma production
cellular response to interferon-beta
B cell proliferation
defense response to bacterium
response to exogenous dsRNA
negative regulation of viral genome replication
innate immune response
leukocyte activation
negative regulation of T cell differentiation
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of multicellular organismal process
defense response to virus
type I interferon signaling pathway
negative regulation of cell adhesion molecule production
neuron cellular homeostasis
cellular response to dsRNA
cellular response to dexamethasone stimulus
positive regulation of transforming growth factor beta production
negative regulation of mononuclear cell migration
receptor signaling pathway via STAT
cellular response to virus
negative regulation of Lewy body formation
antiviral innate immune response
negative regulation of neuroinflammatory response
positive regulation of protein localization to nucleus
negative regulation of matrix metallopeptidase secretion
negative regulation of blood-brain barrier permeability
negative regulation of T-helper 2 cell cytokine production
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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