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Invitrogen
Fra1 Recombinant Rabbit Monoclonal Antibody (8M3Q2)
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FIGURE: 1 / 1
Fra1 Antibody (MA5-57897) in WB
Western blot analysis of Fra1 in HeLa cell lysates (30 µg/lane). HeLa cells were treated by PMA (100 ng/mL) at 37°C for 4 hours after serum-starvation overnight. Samples were incubated overnight at 4°C with Fra1 Recombinant Monoclonal Antibody (Product # MA5-57898) using a dilution of 1:10,000. Followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody at 1:10,000 dilution. Blocking buffer: 3% nonfat dry milk in TBST; Exposure: 30 seconds.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-57897
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
8M3Q2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FRA1 (NP_005429.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.24 mg/mL
Amount
24.8 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI
Target Information
The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FOS like 1, AP-1 trancription factor subunit; FOS-like antigen-1; FOSL1; HGNC:13718; unnamed protein product
Gene Aliases: FRA; fra-1; FRA1
UniProt ID: (Human) P15407
Entrez Gene ID: (Human) 8061
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
chemotaxis
cellular defense response
positive regulation of cell proliferation
response to virus
integrated stress response signaling
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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