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Invitrogen
RANK Recombinant Rabbit Monoclonal Antibody (2Z1P2)
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Product Details
MA5-57951
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2Z1P2
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Amount
19.2 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: IAPPCTSEKH YEHLGRCCNK CEPGKYMSSK CTTTSDSVCL PCGPDEYLDS WNEEDKCLLH KVCDTGKALV AVVAGNSTTP RRCACTAGYH WSQDCECCRR NTECAPGLGA QHPLQLNKDT VCKPCLAGYF SDAFSSTDKC RPWTNCTFLG KRVEHHGTEK SDAVCSSSLP ARKPPNEPHV YLP
Target Information
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD265; familial expansile osteolysis; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TRANCE receptor; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Aliases: CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TNFRSF11A; TRANCE-R; TRANCER
UniProt ID: (Human) Q9Y6Q6
Entrez Gene ID: (Human) 8792
ossification
adaptive immune response
immune system process
monocyte chemotaxis
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to mechanical stimulus
osteoclast differentiation
response to lipopolysaccharide
response to insulin
tumor necrosis factor-mediated signaling pathway
cellular response to zinc ion starvation
response to tumor necrosis factor
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to ethanol
positive regulation of osteoclast differentiation
positive regulation of bone resorption
positive regulation of JNK cascade
lymph node development
circadian temperature homeostasis
mammary gland alveolus development
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
multinuclear osteoclast differentiation
positive regulation of NIK/NF-kappaB signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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