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Invitrogen
PDX1 Recombinant Rabbit Monoclonal Antibody (5H2B1)
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Product Details
MA5-57981
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5H2B1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 184-283 of human PDX1 (NP_000200.1).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.32 mg/mL
Amount
26.4 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
Immunogen sequence: NLTERHIKIW FQNRRMKWKK EEDKKRGGGT AVGGGGVAEP EQDCAVTSGE ELLALPPPPP PGGAVPPAAP VAAREGRLPP GLSASPQPSS VAPRRPQEPR
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DLDBP; E3BP; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; insulin promotor factor 1; IPF-1; islet/duodenum homeobox 1; islet/duodenum homeobox-1; pancreatic and duodenal homeobox gene 1; PDHX; somatostatin transactivating factor 1; somatostatin-transactivating factor 1; STF-1; unnamed protein product
Gene Aliases: IDX-1; Idx1; IPF-1; Ipf1; Mody4; pdx-1; STF-1; Stf1
UniProt ID: (Rat) P52947, (Mouse) P52946
Entrez Gene ID: (Rat) 29535, (Mouse) 18609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
macromolecular complex binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
smoothened signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
response to glucose
response to iron(II) ion
response to chlorate
glucose mediated signaling pathway
regulation of gene expression
morphogenesis of embryonic epithelium
insulin secretion
cell differentiation
pancreas development
exocrine pancreas development
endocrine pancreas development
organ regeneration
response to nutrient levels
positive regulation of insulin secretion
response to vitamin
response to lipid
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of cell proliferation
glucose homeostasis
response to leucine
response to alkaloid
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
response to glucocorticoid
transdifferentiation
epithelium development
response to fatty acid
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
cellular response to acadesine
negative regulation of type B pancreatic cell apoptotic process
embryonic morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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