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Invitrogen

14-3-3 Pan Recombinant Rabbit Monoclonal Antibody (2P9P6)

View all (7) 14-3-3 Pan antibodies

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Product Details

MA5-58079

Applications
Tested Dilution
Publications

Western Blot (WB)

1:3,000-1:18,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2P9P6

Immunogen

Synthetic peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.73 mg/mL

Amount

34.6 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3681101

Target Information

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14-3-3 alpha; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein gamma subtype; 14-3-3 protein gamma-subtype; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein zeta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 sigma protein; 14-3-3 tau; 14-3-3 theta; 14-3-3 zeta; 14-3-3d; 14-3-3E; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; epithelial cell marker protein 1; HS1; KCIP-1; mitochondrial import stimulation factor (MSF) L subunit; mitochondrial import stimulation factor L subunit; mitochondrial import stimulation factor S1 subunit; MME1; MSF L; phospholipase A2; prepronerve growth factor homolog; prepronerve growth factor RNH-1; protein 1054; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein tau; protein, theta; putative protein kinase C regulatory protein; SEZ-2; SFN; signal transduction phosphoprotein; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; unnamed protein product; YWHAG

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Gene Aliases: 1110013I11Rik; 1300003C17Rik; 14-3-3; 14-3-3-zeta; 14-3-3b; 14-3-3E; 14-3-3G; 14-3-3GAMMA; 14-3-3t; 14-3-3z; 14-3-3zeta; 1C5; 2700028P07Rik; D7Bwg1348e; DEE56; EIEE56; Er; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL2; HEL4; HS1; KCIP-1; MDCR; MDS; Mme1; POPCHAS; PPP1R170; YWHAA; YWHAD; YWHAS

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UniProt ID: (Human) P31947, (Mouse) O70456, (Human) P31946, (Human) P62258, (Human) P61981, (Human) P27348, (Human) P63104, (Rat) P35213, (Mouse) Q9CQV8, (Mouse) P62259, (Rat) P62260, (Rat) P61983, (Mouse) P61982, (Rat) P68255, (Mouse) P68254, (Rat) P63102, (Mouse) P63101

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Entrez Gene ID: (Human) 2810, (Mouse) 55948, (Rat) 313017, (Human) 7529, (Human) 7531, (Human) 7532, (Human) 10971, (Human) 7534, (Rat) 56011, (Mouse) 54401, (Mouse) 22627, (Rat) 29753, (Rat) 56010, (Mouse) 22628, (Rat) 25577, (Mouse) 22630, (Rat) 25578, (Mouse) 22631

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Function(s)
protein binding protein kinase C inhibitor activity protein kinase binding identical protein binding cadherin binding phosphoserine binding phosphoprotein binding protein sequestering activity protein kinase inhibitor activity protein phosphatase inhibitor activity enzyme binding protein domain specific binding histone deacetylase binding macromolecular complex binding RNA binding calcium channel regulator activity potassium channel regulator activity calcium channel inhibitor activity protein phosphatase binding MHC class II protein complex binding ubiquitin protein ligase binding signaling adaptor activity ion channel binding protein heterodimerization activity scaffold protein binding molecular function inhibitor activity protein kinase C binding insulin-like growth factor receptor binding receptor tyrosine kinase binding phosphorylation-dependent protein binding 14-3-3 protein binding DNA-binding transcription factor binding enzyme inhibitor activity actin binding enzyme regulator activity
Process(es)
regulation of cyclin-dependent protein serine/threonine kinase activity release of cytochrome c from mitochondria keratinocyte development protein export from nucleus signal transduction protein localization intrinsic apoptotic signaling pathway in response to DNA damage regulation of epidermal cell division negative regulation of keratinocyte proliferation regulation of cell-cell adhesion keratinocyte differentiation positive regulation of cell growth keratinization regulation of protein localization positive regulation of hippo signaling defense response to bacterium skin development establishment of protein localization positive regulation of epidermal cell differentiation positive regulation of keratinocyte differentiation positive regulation of cell adhesion negative regulation of innate immune response positive regulation of protein export from nucleus cytolysis in other organism regulation of cell cycle establishment of skin barrier cAMP/PKA signal transduction non-canonical inflammasome complex assembly negative regulation of protein localization to plasma membrane positive regulation of cellular protein localization protein targeting negative regulation of protein import into nucleus negative regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of cell growth involved in contact inhibition positive regulation of T cell mediated immune response to tumor cell positive regulation of cell-cell adhesion cellular response to insulin stimulus cellular response to glucose starvation regulation of neuron differentiation regulation of synaptic plasticity positive regulation of T cell activation negative regulation of TORC1 signaling negative regulation of transcription from RNA polymerase II promoter angiogenesis respiratory system process protein phosphorylation synaptic target recognition lung development regulation of protein stability tube formation negative regulation of apoptotic process establishment of Golgi localization regulation of ERK1 and ERK2 cascade regulation of synapse maturation Golgi reassembly negative regulation of protein localization to nucleus small GTPase mediated signal transduction negative regulation of ion transmembrane transport histamine secretion by mast cell response to xenobiotic stimulus regulation of programmed cell death ERK1 and ERK2 cascade protein localization to mitochondrion cytoplasmic translation negative regulation of T cell mediated immune response to tumor cell SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels cellular response to amino acid starvation TORC1 signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of translational initiation positive regulation of translational initiation protein stabilization negative regulation of T cell activation protein localization to lysosome protein K6-linked ubiquitination positive regulation of TORC1 signaling substantia nigra development MAPK cascade cytoplasmic pattern recognition receptor signaling pathway regulation of heart rate by hormone regulation of mitotic cell cycle cellular potassium ion homeostasis negative regulation of toll-like receptor signaling pathway protein localization to nucleus cellular response to heat intracellular signal transduction regulation of cytosolic calcium ion concentration regulation of membrane repolarization protein localization to endoplasmic reticulum membrane repolarization during cardiac muscle cell action potential regulation of heart rate by cardiac conduction regulation of potassium ion transmembrane transport negative regulation of calcium ion export across plasma membrane neuron migration ER to Golgi vesicle-mediated transport Golgi to plasma membrane transport hippocampus development cerebral cortex development positive regulation of toll-like receptor signaling pathway toll-like receptor 4 signaling pathway hippo signaling protein K11-linked ubiquitination regulation of postsynaptic membrane neurotransmitter receptor levels lysosome organization antibacterial innate immune response regulation of lysosome organization biological_process negative regulation of protein kinase activity regulation of signal transduction
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