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Invitrogen

Neuropilin 1 Recombinant Rabbit Monoclonal Antibody (6J4A3)

View all (55) Neuropilin 1 (CD304) antibodies

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Neuropilin 1 Recombinant Rabbit Monoclonal Antibody (6J4A3)

Product Details

MA5-58215

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6J4A3

Immunogen

Recombinant protein (or fragment)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.65 mg/mL

Amount

33 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3681235

Product Specific Information

Immunogen sequence: FRSDKCGGTI KIENPGYLTS PGYPHSYHPS EKCEWLIQAP EPYQRIMINF NPHFDLEDRD CKYDYVEVID GENEGGRLWG KFCGKIAPSP VVSSGPFLFI KFVSDYETHG AGFSIRYEIF KRGPECSQNY TAPTGVIKSP GFPEKYPNSL ECTYIIFAPK MSEIILEFES FDLEQDSNPP GGMFCRYDRL EIWDGFPEVG PHIGRYCGQK TPGRIRSSSG VLSMVFYTDS AIAKEGFSAN YSVLQSSISE DFKCM

Target Information

Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. Expressed mostly in the nervous system this receptor is implicated in a wide range of functions including in the development of the cardiovascular system, angiogenesis, repulsive axon guidance, formation of certain neuronal circuits, cell survival, control of neuronal migration and organogenesis outside the nervous system. This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. Neuropilin 1 may be involved in aggressive advanced prostate carcinoma and in the progression of breast cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A5 protein; alternatively spliced; lacks exon 16; Neuropilin; Neuropilin-1 precursor (A5 protein); Neuropilin1; NRP 1; receptor for VEGF165 and semaphorins class 3; sNRP 1; sNRP1; soluble NRP 1; soluble NRP1; transmembrane receptor; type I transmembrane protein; unnamed protein product; vascular endothelial cell growth factor 165 receptor; VEGF 165 receptor

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Gene Aliases: BDCA4; C530029I03; CD304; NP-1; NP1; NPN-1; Npn1; NRP; VEGF165R

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UniProt ID: (Human) O14786, (Rat) Q9QWJ9, (Mouse) P97333

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Entrez Gene ID: (Human) 8829, (Rat) 246331, (Mouse) 18186

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Function(s)
vascular endothelial growth factor-activated receptor activity GTPase activator activity protein binding coreceptor activity semaphorin receptor activity growth factor binding protein kinase binding cytokine binding vascular endothelial growth factor binding
Process(es)
angiogenesis patterning of blood vessels vasculogenesis neural crest cell migration neuron migration sprouting angiogenesis cell migration involved in sprouting angiogenesis outflow tract septum morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis substrate-dependent cell migration, cell extension integrin-mediated signaling pathway nervous system development axon guidance axonal fasciculation heart development motor neuron axon guidance response to wounding positive regulation of endothelial cell migration positive regulation of platelet-derived growth factor receptor signaling pathway dendrite development cell migration facial nerve structural organization trigeminal nerve morphogenesis trigeminal nerve structural organization vestibulocochlear nerve structural organization branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus positive regulation of cell migration negative regulation of axon extension regulation of vascular endothelial growth factor receptor signaling pathway retinal ganglion cell axon guidance regulation of Cdc42 protein signal transduction cellular response to hepatocyte growth factor stimulus endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus ventral trunk neural crest cell migration vascular endothelial growth factor signaling pathway neuropilin signaling pathway VEGF-activated neuropilin signaling pathway wound healing positive regulation of phosphorylation negative regulation of neuron apoptotic process endothelial cell migration positive regulation of angiogenesis platelet-derived growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway sympathetic nervous system development neuron development regulation of axon extension involved in axon guidance positive regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance artery morphogenesis axon extension involved in axon guidance positive chemotaxis positive regulation of chemotaxis positive regulation of filopodium assembly positive regulation of stress fiber assembly positive regulation of focal adhesion assembly axonogenesis involved in innervation dichotomous subdivision of terminal units involved in salivary gland branching angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis retina vasculature development in camera-type eye retina vasculature morphogenesis in camera-type eye renal artery morphogenesis sympathetic ganglion development trigeminal ganglion development positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway positive regulation of smooth muscle cell chemotaxis commissural neuron axon guidance positive regulation of cell migration involved in sprouting angiogenesis sensory neuron axon guidance motor neuron migration sympathetic neuron projection extension sympathetic neuron projection guidance postsynapse organization basal dendrite development basal dendrite arborization positive regulation of substrate adhesion-dependent cell spreading neural crest cell migration involved in autonomic nervous system development protein localization to early endosome facioacoustic ganglion development positive regulation of vascular associated smooth muscle cell migration dorsal root ganglion morphogenesis otic placode development negative regulation of extrinsic apoptotic signaling pathway viral entry into host cell cell migration involved in coronary vasculogenesis positive regulation of endothelial cell proliferation signal transduction cell-cell signaling organ morphogenesis positive regulation of smooth muscle cell migration regulation of vesicle-mediated transport endothelial tip cell fate specification regulation of plasma membrane bounded cell projection organization
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