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Invitrogen

RAGE (Biosimilar) Recombinant Human Monoclonal Antibody

View all (27) RAGE antibodies

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Product Details

MA5-58759

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL once reconstituted

Amount

100 µg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3681779

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This antibody can also be cross referenced by the term XT-M4.

This product is a Humanized rat antibody.

Target Information

The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-beta peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-kB activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: advanced glycosylation end product receptor; advanced glycosylation end product-specific receptor; RAGE-4 ORF3; RAGEdelex2-6; RAGEdelex3; RAGEdelex3-10; RAGEdelex3-7; RAGEdelex8&int9; RAGEint4; RAGEint4&9; RAGEint9&delex11; RAGEv1; RAGEv8; receptor for advanced glycation end-products; soluble receptor; sRAGE; unnamed protein product

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Gene Aliases: RAGE; SCARJ1; sRAGE

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UniProt ID: (Human) Q15109

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Entrez Gene ID: (Human) 177

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Function(s)
beta-amyloid binding DNA binding RNA binding transmembrane signaling receptor activity scavenger receptor activity protein binding signaling receptor activity histone binding identical protein binding S100 protein binding macromolecular complex binding advanced glycation end-product receptor activity binding, bridging
Process(es)
microglial cell activation positive regulation of cytokine production regulation of T cell mediated cytotoxicity phagocytosis inflammatory response cell surface receptor signaling pathway learning or memory positive regulation of cell proliferation response to wounding glucose mediated signaling pathway astrocyte development regulation of cell adhesion positive regulation of cell migration neuron projection development negative regulation of interleukin-10 production positive regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-12 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of heterotypic cell-cell adhesion intracellular signal transduction positive regulation of activated T cell proliferation transcytosis positive regulation of cell differentiation positive regulation of JNK cascade astrocyte activation regulation of synaptic plasticity regulation of inflammatory response positive regulation of DNA metabolic process negative regulation of multicellular organismal process positive regulation of ERK1 and ERK2 cascade cellular response to glucose stimulus regulation of spontaneous synaptic transmission transport across blood-brain barrier regulation of long-term synaptic potentiation negative regulation of long-term synaptic potentiation negative regulation of long term synaptic depression regulation of p38MAPK cascade positive regulation of p38MAPK cascade regulation of NIK/NF-kappaB signaling positive regulation of NIK/NF-kappaB signaling positive regulation of amyloid precursor protein catabolic process negative regulation of blood circulation positive regulation of endothelin production response to amyloid-beta cellular response to beta-amyloid positive regulation of DNA-dependent DNA replication positive regulation of monocyte extravasation regulation of CD4-positive, alpha-beta T cell activation positive regulation of double-strand break repair positive regulation of dendritic cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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