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Invitrogen
CD105 (Endoglin) (Carotuximab Biosimilar) Recombinant Human Monoclonal Antibody
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FIGURE: 1 / 1
CD105 (Endoglin) (Carotuximab Biosimilar) Antibody (MA5-58819) in SDS-PAGE
SDS-PAGE analysis of CD105 (Endoglin) (Carotuximab Biosimilar) Recombinant monoclonal antibody (Product # MA5-58819). Samples were run under reducing (R) condition. The purity of the protein is greater than 90%.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-58819
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
MA5-58819 is a human/mouse chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105 antigen; circulating isoform of endoglin TGF-beta receptor type III; endoglin precursor; ORW; soluble endoglin; unnamed protein product
Gene Aliases: END; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
transmembrane signaling receptor activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
coreceptor activity
receptor activator activity
type I transforming growth factor beta receptor binding
BMP binding
identical protein binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
vasculogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
heart looping
sprouting angiogenesis
positive regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
regulation of transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
regulation of cell adhesion
negative regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
dorsal aorta morphogenesis
wound healing
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
positive regulation of protein kinase B signaling
atrial cardiac muscle tissue morphogenesis
cell chemotaxis
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
detection of hypoxia
endocardial cushion to mesenchymal transition
vascular smooth muscle cell development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of vascular smooth muscle cell differentiation
atrioventricular canal morphogenesis
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of cell proliferation involved in heart morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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