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Invitrogen
Nogo Receptor (Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-58903
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG2SA
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Abbott patent anti-NGR.
Target Information
NOGO (RTN4R) is a receptor for RTN4, OMG, and MAG. Its signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. NOGO also mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. In addition, NOGO acts with RTN4 and LINGO1 to regulate neuronal precursor cell motility during cortical development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Em:AC007663.1; HGNC:1860; NgR; nogo 66 receptor; Nogo receptor; Nogo-66 receptor; OTTHUMP00000197866; Reticulon-4 receptor; UNQ330/PRO526
Gene Aliases: NGR; NOGOR; RTN4R; UNQ330/PRO526
UniProt ID: (Human) Q9BZR6
Entrez Gene ID: (Human) 65078
cell surface receptor signaling pathway
axonogenesis
negative regulation of neuron projection development
corpus callosum development
neuronal signal transduction
negative regulation of axon extension
positive regulation of Rho protein signal transduction
positive regulation of GTPase activity
negative regulation of axon regeneration
regulation of synapse assembly
regulation of postsynapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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