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Invitrogen
VEGF Receptor 1 (Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-59069
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL once reconstituted
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Abbott patent anti-Flt1.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fms related tyrosine kinase 1; fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; kinase domain; protein kinase; sFLT1-14; soluble VEGF receptor; soluble VEGFR 1; sVEGFR 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; unnamed protein product; vascular endothelial growth factor receptor/VEGF receptor/cell surface tyrosine kinase; vascular permeability factor receptor; VEGF R1; VEGFR1 variant; VEGFR; tyrosine kinase
Gene Aliases: FLT; FLT-1; VEGFR-1; VEGFR1
UniProt ID: (Human) P17948
Entrez Gene ID: (Human) 2321
sprouting angiogenesis
monocyte chemotaxis
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
cellular response to vascular endothelial growth factor stimulus
vascular endothelial growth factor receptor-1 signaling pathway
vascular endothelial growth factor signaling pathway
regulation of cell proliferation
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
blood vessel morphogenesis
embryonic morphogenesis
positive regulation of developmental process
positive regulation of protein kinase B signaling
negative regulation of vascular endothelial cell proliferation
hyaloid vascular plexus regression
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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