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Invitrogen
IFN alpha (Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-59107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Baylor patent anti-IFN alpha.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; cytokine; ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha-1/13; IFN-ALPHA-2; IFN-ALPHAA; IFNA; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha leukocyte (IFL); interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; interferon alpha-D; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); interferon-alpha1; LEIF A; MGC138207; MGC138505; MGC138507; unnamed protein product
Gene Aliases: IFL; IFN; IFN-ALPHA; IFN-alpha-2; IFN-alphaA; IFN-alphaD; IFNA; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; leIF A; leIF D
UniProt ID: (Human) P01563
Entrez Gene ID: (Human) 3439, (Human) 3440
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
defense response
humoral immune response
response to exogenous dsRNA
viral entry into host cell
defense response to virus
type I interferon signaling pathway
cellular response to virus
antiviral innate immune response
apoptotic process
inflammatory response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
receptor signaling pathway via STAT
negative regulation of T-helper 2 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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