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Invitrogen
MCK10 (Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-59429
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Imperial College anti-DDR1.
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD167 antigen-like family member A; cell adhesion kinase; DAAP-278B20.1; DDR1d; juxtamembrane region; mammary carcinoma kinase 10; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase, receptor, type 4; protein-tyrosine kinase RTK-6; PTK3A protein tyrosine kinase 3A; tyrosine kinase DDR; tyrosine-protein kinase CAK; unnamed protein product
Gene Aliases: CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
UniProt ID: (Human) Q08345
Entrez Gene ID: (Human) 780
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of extracellular matrix disassembly
positive regulation of neuron projection development
smooth muscle cell migration
collagen-activated tyrosine kinase receptor signaling pathway
peptidyl-tyrosine autophosphorylation
wound healing, spreading of cells
protein autophosphorylation
positive regulation of protein kinase B signaling
smooth muscle cell-matrix adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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