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Invitrogen
HAMP (Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-59475
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG4SP
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term LY2787106.
This product is a Humanized mouse antibody.
Target Information
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antimicrobial peptide precursor; hepcidin preproprotein; liver-expressed antimicrobial peptide 1; putative liver tumor regressor
Gene Aliases: HEPC; HFE2B; LEAP1; PLTR
UniProt ID: (Human) P81172
Entrez Gene ID: (Human) 57817
negative regulation of transcription from RNA polymerase II promoter
positive regulation of receptor internalization
cellular iron ion homeostasis
immune response
signal transduction
response to iron ion
killing of cells of other organism
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of iron ion transmembrane transport
defense response to bacterium
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
cation homeostasis
multicellular organismal iron ion homeostasis
antimicrobial humoral immune response mediated by antimicrobial peptide
inorganic ion homeostasis
positive regulation of protein polyubiquitination
negative regulation of iron export across plasma membrane
negative regulation of intestinal absorption
positive regulation of receptor catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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