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Invitrogen

TGFBR2 (Biosimilar) Recombinant Human Monoclonal Antibody

View all (25) TGFBR2 antibodies

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Product Details

MA5-59802

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

1 mg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3682821

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This antibody can also be cross referenced by the term LY3022859.

Target Information

Transforming Growth Factor, beta receptor 2 (AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII) is a member of the TGF-beta family of receptor Serine/Threonine kinases. It is involved in the regulation of cell proliferation. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). TGFBR2 encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. TGFBR2 also has a pseudogene on chromosome 14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ser/Thr protein kinase; tgf beta receptor 2; TGF-beta receptor type IIB; TGF-beta type II receptor; TGFbeta RII; TGFBR2-SE; TGFR2; transforming growth factor beta receptor II; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_1; transforming growth factor beta receptor II (70/80kDa) isoform TGFBR2_2; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; unnamed protein product

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Gene Aliases: AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; tbetaR-II; TBR-ii; TBRII; TGFbeta-RII; TGFR-2

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UniProt ID: (Human) P37173

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Entrez Gene ID: (Human) 7048

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Function(s)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II protein binding ATP binding glycosaminoglycan binding activin receptor activity, type I kinase activator activity type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding signaling receptor activity SMAD binding metal ion binding activin binding transforming growth factor beta binding binding, bridging
Process(es)
blood vessel development patterning of blood vessels vasculogenesis epithelial to mesenchymal transition heart looping positive regulation of mesenchymal cell proliferation positive regulation of tolerance induction to self antigen positive regulation of B cell tolerance induction positive regulation of T cell tolerance induction outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis tricuspid valve morphogenesis cardiac left ventricle morphogenesis endocardial cushion fusion apoptotic process transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway nervous system development brain development heart development positive regulation of cell proliferation response to xenobiotic stimulus positive regulation of epithelial to mesenchymal transition cell differentiation activin receptor signaling pathway response to lipid embryonic hemopoiesis aorta morphogenesis regulation of cell proliferation myeloid dendritic cell differentiation animal organ development blood vessel morphogenesis embryonic cranial skeleton morphogenesis artery morphogenesis positive regulation of developmental process positive regulation of NK T cell differentiation cartilage development regulation of multicellular organismal process palate development positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis secondary palate development response to cholesterol cellular response to growth factor stimulus positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cell proliferation involved in endocardial cushion morphogenesis superior endocardial cushion morphogenesis inferior endocardial cushion morphogenesis miRNA transport positive regulation of reactive oxygen species metabolic process positive regulation of CD4-positive, alpha-beta T cell proliferation regulation of stem cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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