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Invitrogen

FLK1 (VEGF Receptor 2) (Biosimilar) Recombinant Human Monoclonal Antibody

View all (81) FLK1 (VEGF Receptor 2) antibodies

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Product Details

MA5-59909

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Surface plasmon resonance (SPR)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL once reconstituted

Amount

100 µg

Purification

Protein A

Storage buffer

25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

RRID

AB_3682928

Product Specific Information

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

This antibody can also be cross referenced by the term AT001.

Target Information

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD309 antigen; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; sCD309; soluble CD309; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; unnamed protein product; VEGF R2; VEGFR-2; tyrosine kinase

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Gene Aliases: CD309; FLK1; VEGFR; VEGFR2

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UniProt ID: (Human) P35968

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Entrez Gene ID: (Human) 3791

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding coreceptor activity growth factor binding vascular endothelial growth factor binding identical protein binding cadherin binding Hsp90 protein binding
Process(es)
angiogenesis patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development endocardium development endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape positive regulation of endothelial cell migration negative regulation of gene expression positive regulation of macroautophagy cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration positive regulation of BMP signaling pathway embryonic hemopoiesis cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor signaling pathway negative regulation of apoptotic process regulation of MAPK cascade positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration endothelial cell differentiation positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling positive regulation of mitochondrial depolarization epithelial tube morphogenesis vascular wound healing positive regulation of ERK1 and ERK2 cascade semaphorin-plexin signaling pathway positive regulation of cell migration involved in sprouting angiogenesis positive regulation of mitochondrial fission positive regulation of nitric oxide-cGMP mediated signal transduction cellular response to hydrogen sulfide negative regulation of endothelial cell apoptotic process positive regulation of endothelial cell chemotaxis positive regulation of vasculogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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