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Invitrogen
CD156A/EGFR (Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-60143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Target Information
The CD156A gene, also known as ADAM8 (a disintegrin and metalloprotease 8), is a cell surface antigen highly expressed in monocytic lineages, with a significant role in neurodegenerative diseases and cancer. It is a membrane-anchored metalloprotease with a long extracellular region containing domains similar to hemorrhagic snake venom proteins. ADAM8 is involved in the regulation of cell adhesion and proteolysis. The gene encoding CD156A is located on human chromosome 10q26.3.
Meanwhile, the EGFR gene, or epidermal growth factor receptor, is part of the ErbB family of receptor tyrosine kinases located on chromosome 7p11.2. EGFR plays a crucial role in regulating cell proliferation, differentiation, survival, and migration. It is a 170-kDa transmembrane glycoprotein and is heavily implicated in various cancers, including non-small-cell lung cancer and glioblastoma due to mutations or overexpressions. Both genes are critical for cell communication and regulation processes, with significant implications for cancer therapy and neurodegenerative disease research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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