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Invitrogen
HCoV-NL63 Spike S1/S2 Recombinant Rabbit Monoclonal Antibody (279)
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Product Details
MA5-60552
Product Specifications
Species Reactivity
Virus
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
279
Immunogen
Recombinant HCoV-NL63 Spike S1/S2 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recognize the Spike of HCoV-NL63 in ELISA. Doesn't recognize the Spike of SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, HCoV-HKU1 (isolate N5), HCoV-OC43.. Has cross-reactivity in ELISA with: HCoV-NL63 Spike S1+S2 ECD-His; No cross-reactivity in ELISA with: SARS-CoV-2 Spike S1-His; SARS-CoV-2 Spike S1 NTD-Fc & AVI; SARS-CoV-2 Spike S1 NTD-His & AVI; SARS-CoV-2 Spike RBD-His; SARS-CoV-2 Spike S1+S2 ECD-His; SARS-CoV-2 Spike S2 ECD-His; SARS-CoV Spike S1+S2 ECD-His; MERS-CoV Spike S1+S2 ECD-His; HCoV-229E Spike S1+S2 ECD-His; HCoV-OC43 Spike S1+S2 ECD-His; HCoV-HKU1 (isolate N5) Spike S1+S2 ECD-His
Target Information
HCoV-NL63 Spike S1/S2 refers to the specific regions of the spike (S) protein of the Human Coronavirus NL63 (HCoV-NL63), which is a virus known to cause respiratory infections, including the common cold, particularly in children, the elderly, and immunocompromised individuals. The spike protein is essential for viral entry into host cells and is composed of two subunits: S1, which contains the receptor-binding domain (RBD) responsible for attaching to the host cell receptor angiotensin-converting enzyme 2 (ACE2), and S2, which facilitates the fusion of the viral and host cell membranes. The S1/S2 cleavage site is a critical juncture where host proteases cleave the spike protein, activating it for membrane fusion and subsequent viral entry. Understanding the structure and function of these regions is crucial for developing targeted therapies and vaccines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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