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Invitrogen
HDAC2 Recombinant Rabbit Monoclonal Antibody (9E9)
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FIGURE: 1 / 2
HDAC2 Antibody (MA5-60654) in IHC (P)
Immunohistochemistry analysis of HDAC2 in paraffin-embedded human breast cancer. Samples were incubated with HDAC2 Recombinant Monoclonal antibody (Product # MA5-60654) using a dilution of 1:100 followed by detection with Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Sect... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-60654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
9E9
Immunogen
A synthesized peptide derived from human HDAC2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hdac 2; hdac-2; protein deacylase HDAC2; transcriptional regulator homolog RPD3; unnamed protein product; YY1-associated factor 1
Gene Aliases: HD2; KDAC2; RPD3; YAF1
UniProt ID: (Human) Q92769
Entrez Gene ID: (Human) 3066
transcription cofactor binding
chromatin binding
RNA binding
histone deacetylase activity
protein binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
enzyme binding
nucleosomal DNA binding
protein deacetylase activity
histone binding
histone deacetylase binding
NF-kappaB binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
protein de-2-hydroxyisobutyrylase activity
protein lysine delactylase activity
negative regulation of transcription from RNA polymerase II promoter
chromatin remodeling
positive regulation of cell proliferation
epidermal cell differentiation
negative regulation of neuron projection development
dendrite development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
heterochromatin assembly
circadian regulation of gene expression
positive regulation of intracellular estrogen receptor signaling pathway
odontogenesis of dentin-containing tooth
regulation of cell fate specification
embryonic digit morphogenesis
negative regulation of apoptotic process
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
progesterone receptor signaling pathway
hair follicle placode formation
eyelid development in camera-type eye
fungiform papilla formation
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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