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Invitrogen
SOD2 Recombinant Rabbit Monoclonal Antibody (10F6)
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FIGURE: 1 / 2
SOD2 Antibody (MA5-60655) in IHC (P)
Immunohistochemistry analysis of SOD2 in paraffin-embedded human liver cancer. Samples were incubated with SOD2 Recombinant Monoclonal antibody (Product # MA5-60655) using a dilution of 1:100 followed by detection with Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-60655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
10F6
Immunogen
A synthesized peptide derived from human SOD2.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; gastric cancer-associated lncRNA 1; GC1; GClnc1; indophenoloxidase B; IPO B; IPO-B; IPOB; lncRNA-GC1; manganese superoxide dismutase; manganese-containing superoxide dismutase; mangano-superoxide dismutase; mitochondrial superoxide dismutase 2; Mn superoxide dismutase; Mn-SOD; Mn-superoxide dismutase; MNSOD; MVCD6; Superoxide dimutase 2, mitochondrial; superoxide dismutase; superoxide dismutase 2, mitochondrial; unnamed protein product
Gene Aliases: GC1; GClnc1; IPO-B; IPOB; lncRNA-GC1; Mn-SOD; MNSOD; MVCD6
UniProt ID: (Human) P04179, (Rat) P07895
Entrez Gene ID: (Human) 6648, (Rat) 24787
response to superoxide
response to hypoxia
release of cytochrome c from mitochondria
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
regulation of transcription from RNA polymerase II promoter
superoxide metabolic process
response to oxidative stress
regulation of blood pressure
negative regulation of cell proliferation
response to xenobiotic stimulus
response to manganese ion
response to zinc ion
response to selenium ion
positive regulation of hydrogen peroxide biosynthetic process
response to activity
removal of superoxide radicals
positive regulation of cell migration
response to nutrient levels
oxygen homeostasis
response to lipopolysaccharide
response to L-ascorbic acid
response to silicon dioxide
cellular response to oxidative stress
response to isolation stress
response to immobilization stress
response to hydrogen peroxide
hydrogen peroxide metabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
response to cadmium ion
hydrogen peroxide biosynthetic process
protein homotetramerization
response to electrical stimulus
response to magnetism
cellular response to ethanol
positive regulation of phenotypic switching
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of membrane hyperpolarization
negative regulation of vascular smooth muscle cell proliferation
positive regulation of vascular smooth muscle cell differentiation
positive regulation of vascular associated smooth muscle cell apoptotic process
response to reactive oxygen species
liver development
detection of oxygen
glutathione metabolic process
mitochondrion organization
heart development
locomotory behavior
intrinsic apoptotic signaling pathway in response to DNA damage
intrinsic apoptotic signaling pathway in response to oxidative stress
apoptotic mitochondrial changes
post-embryonic development
response to gamma radiation
respiratory electron transport chain
hemopoiesis
vasodilation
superoxide anion generation
positive regulation of nitric oxide biosynthetic process
negative regulation of fat cell differentiation
negative regulation of fibroblast proliferation
neuron development
response to axon injury
erythrophore differentiation
regulation of catalytic activity
regulation of mitochondrial membrane potential
response to hyperoxia
multicellular organismal iron ion homeostasis
response to oxygen levels
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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