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Invitrogen
Synaptophysin Recombinant Mouse Monoclonal Antibody (2B2)
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FIGURE: 1 / 3
Synaptophysin Antibody (MA5-60747) in ICC/IF
Immunocytochemistry analysis of Synaptophysin in Hela cells. Samples were incubated with Synaptophysin Recombinant Monoclonal antibody (Product # MA5-60747) using a dilution of 1:200 followed by FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). Counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight... View More
Product Details
MA5-60747
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, Fc
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
2B2
Immunogen
Recombinant Human SYP protein.
Conjugate
Form
Liquid
Concentration
5.93 mg/mL
Amount
593 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Major synaptic vesicle protein p38; Synaptophysin; unnamed protein product
Gene Aliases: MRX96; MRXSYP; SYP; XLID96
UniProt ID: (Human) P08247
Entrez Gene ID: (Human) 6855
endocytosis
regulation of synaptic vesicle priming
synaptic vesicle maturation
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
synaptic vesicle membrane organization
modulation of synaptic transmission
regulation of opioid receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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