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Invitrogen
SIGLEC8 Recombinant Human Monoclonal Antibody (18D13)
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FIGURE: 1 / 1
SIGLEC8 Antibody (MA5-60809) in IHC (P)
Immunohistochemistry analysis of SIGLEC8 in paraffin-embedded human prostate cancer. Samples were incubated with SIGLEC8 Recombinant Monoclonal antibody (Product # MA5-60809) using a dilution of 1:100 followed by detection with Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0).... View More
Product Details
MA5-60809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
18D13
Immunogen
Recombinant Human SIGLEC8 protein.
Conjugate
Form
Liquid
Concentration
1.94 mg/mL
Amount
194 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDw329; member of sialoadhesin family; MGC59785; SAF-2; Sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; Siglec; Siglec-8; unnamed protein product
Gene Aliases: SAF2; SIGLEC-8; SIGLEC8; SIGLEC8L
UniProt ID: (Human) Q9NYZ4
Entrez Gene ID: (Human) 27181
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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