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Invitrogen
TSH Receptor Recombinant Human Monoclonal Antibody (11A5)
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FIGURE: 1 / 2
TSH Receptor Antibody (MA5-60830) in Flow
Flow cytometry of TSH Receptor in untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line). Samples were incubated with TSH Receptor Recombinant Monoclonal antibody (Product # MA5-60830) followed by APC-conjugated anti-Human IgG Fc.
Product Details
MA5-60830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
11A5
Immunogen
Recombinant Human TSHR protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G-protein coupled receptor; TSHR; MGC141920; seven transmembrane helix receptor; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH receptor; TSH-R; unnamed protein product
Gene Aliases: CHNG1; hTSHR-I; LGR3; TSHR
UniProt ID: (Human) P16473
Entrez Gene ID: (Human) 7253
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of cell proliferation
response to hormone
hormone-mediated signaling pathway
thyroid-stimulating hormone signaling pathway
positive regulation of cold-induced thermogenesis
cellular response to glycoprotein
cellular response to thyrotropin-releasing hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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