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Invitrogen
SMO Monoclonal Antibody (1015418)
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Product Details
MA5-60873
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1015418
Immunogen
Chinese Hamster Ovary cell line, CHO-derived human Smoothened, Met1-Tyr233
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: candidate receptor for sonic hedgehog; frizzled family member 11; HGNC:11119; Protein Gx; Protein SMOH; Protein smoothened; seven transmembrane helix receptor; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Gene Aliases: CRJS; FZD11; Gx; PHLS; SMO; SMOH
UniProt ID: (Human) Q99835
Entrez Gene ID: (Human) 6608
negative regulation of transcription from RNA polymerase II promoter
ossification
vasculogenesis
osteoblast differentiation
in utero embryonic development
cell fate specification
neural crest cell migration
negative regulation of protein phosphorylation
hair follicle development
heart looping
positive regulation of neuroblast proliferation
positive regulation of mesenchymal cell proliferation
heart morphogenesis
determination of left/right asymmetry in lateral mesoderm
type B pancreatic cell development
protein import into nucleus
apoptotic process
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
smoothened signaling pathway
determination of left/right symmetry
ventral midline determination
pattern specification process
neuroblast proliferation
central nervous system development
midgut development
cell proliferation
positive regulation of cell proliferation
tissue development
anterior/posterior pattern specification
dorsal/ventral pattern formation
gene expression
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
spinal cord dorsal/ventral patterning
dentate gyrus development
cerebellar cortex morphogenesis
thalamus development
dorsal/ventral neural tube patterning
central nervous system neuron differentiation
cerebral cortex development
positive regulation of cell migration
epithelial cell differentiation
negative regulation of epithelial cell differentiation
hair follicle morphogenesis
protein localization to nucleus
multicellular organism growth
positive regulation of multicellular organism growth
positive regulation of protein import into nucleus
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
astrocyte activation
cell development
digestive tract development
embryonic organ development
developmental growth
skeletal muscle fiber development
smooth muscle tissue development
forebrain morphogenesis
homeostasis of number of cells within a tissue
epithelial cell proliferation
positive regulation of epithelial cell proliferation
protein stabilization
myoblast migration
negative regulation of hair follicle development
contact inhibition
atrial septum morphogenesis
mammary gland epithelial cell differentiation
epithelial-mesenchymal cell signaling
somite development
pancreas morphogenesis
left/right axis specification
cellular response to cholesterol
dopaminergic neuron differentiation
commissural neuron axon guidance
mesenchymal to epithelial transition involved in metanephric renal vesicle formation
positive regulation of branching involved in ureteric bud morphogenesis
response to inositol
regulation of somatic stem cell population maintenance
regulation of heart morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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