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Invitrogen
FRZB Monoclonal Antibody (133931)
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Product Details
MA5-61065
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
133931
Immunogen
Mouse myeloma cell line NS0-derived recombinant human sFRP-3, Ala33-Asn325
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FREOS1; frezzled; frizzled homolog-related; frizzled-related protein 1; FRZB1sFRP-3; secreted frizzled-related sequence protein 3; sFRP-3; SFRP3frezzled; unnamed protein product
Gene Aliases: FRE; frezzled; FRITZ; Frp; FRP-3; FRZB-1; FRZB-PEN; FRZB1; FZRB; hFIZ; OS1; SFRP3; SRFP3
UniProt ID: (Human) Q92765, (Mouse) P97401
Entrez Gene ID: (Human) 2487, (Mouse) 20378
negative regulation of cell proliferation
negative regulation of cell development
neural crest cell differentiation
negative regulation of Wnt signaling pathway
negative regulation of cell growth
non-canonical Wnt signaling pathway
inner ear morphogenesis
positive regulation of apoptotic process
regulation of cell differentiation
positive regulation of fat cell differentiation
convergent extension involved in organogenesis
canonical Wnt signaling pathway
negative regulation of cartilage development
somite development
negative regulation of hepatocyte differentiation
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
skeletal system development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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