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Invitrogen
TRAF3 Isoform 2 Monoclonal Antibody (433113)
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Product Details
MA5-61287
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
433113
Immunogen
E. coli-derived recombinant human TRAF-3, Met1-Pro543
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
250 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
TRAF3 Isoform 2 is a variant of the TNF receptor-associated factor 3 (TRAF3) gene, which plays a crucial role in the regulation of immune responses, inflammation, and cell survival. TRAF3 is a part of the TRAF protein family, which mediates signal transduction from various receptors of the TNF receptor superfamily, Toll-like receptors (TLRs), and other immune receptors. Isoform 2 of TRAF3 may have distinct regulatory functions compared to the canonical form, potentially influencing specific signaling pathways. TRAF3 is known to act as a negative regulator of the non-canonical NF-kappaB signaling pathway, which is important for immune homeostasis and prevention of chronic inflammation. Alterations or mutations in TRAF3, including its isoforms, have been associated with various diseases, including autoimmune disorders, lymphomas, and other cancers. Research into TRAF3 Isoform 2 could provide insights into its unique roles and therapeutic potential in modulating immune responses and treating related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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