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Invitrogen
Cyclophilin A Monoclonal Antibody (817815)
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Product Details
MA5-61325
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
817815
Immunogen
E. coli-derived recombinant human Cyclophilin A, Met1-Glu165
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HGNC:9253; MGC117158; MGC12404; MGC23397; Peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; Rotamase A; T cell cyclophilin; unnamed protein product
Gene Aliases: CYPA; CYPH; HEL-S-69p; PPIA
UniProt ID: (Human) P62937
Entrez Gene ID: (Human) 5478
protein peptidyl-prolyl isomerization
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein folding
negative regulation of protein kinase activity
apoptotic process
viral release from host cell
platelet activation
neuron differentiation
neutrophil chemotaxis
leukocyte chemotaxis
activation of protein kinase B activity
negative regulation of stress-activated MAPK cascade
lipid particle organization
cellular response to oxidative stress
endothelial cell activation
positive regulation of MAPK cascade
regulation of viral genome replication
positive regulation of viral genome replication
positive regulation of protein secretion
positive regulation of NF-kappaB transcription factor activity
cell adhesion molecule production
negative regulation of protein K48-linked ubiquitination
platelet aggregation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of viral life cycle
regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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